Toon Town is the point where The Animation connects to Hollywood, occupying the space of approximately three city blocks on the Hollywood side. It resembles a mirror image of Hollywood's urban sprawl. This is either a possible example of sub-quantum entanglement or just a very weird coincidence.
- Main article: Dollop Hills
Whether old money or new money, you are welcome in Dollop Hills as long as you have money. The richest of the rich and other society elites make their homes here, usually sprawling mansions or stately townhouses. The area also hosts two of the oldest, most prestigious universities in the Animation, Pimento University and Inkwell University.
- Main article: Katzen Docks
Where the Mudson River meets the Specific Ocean is Toon Town's busiest port, Katzen Docks. By reason of it being the only port. As well as shipyards and warehouses, the area boasts the most nautical-themed bars and saloons per square mile. Nearby Ingress Island, with the Statue of Lunacy, serves as one of the great symbols of Toon Town.
- Main article: Monsterville
Located entirely underneath the south end of the Schnooklyn Bridge, Monsterville is home to Toon Town's most visibly monstrous inhabitants, hence its incredibly accurate name. With mixed architecture and bad-tempered local residents, it's not recommended for tourists.
- Main article: Schnooklyn
The part of Toon Town that crosses over with Hollywood, Schnooklyn is also known as "Downtown Toon Town" by locals. It is bordered on its east side by the Mudson River. Much of Toon Town's business and industries are sited here, including Acme Labs and the First National Bank of Toon Town.
- Main article: SoSo
Not the best district in Toon Town, but not the worst. Mostly sleepy suburbs punctuated by the occasional mall, SoSo is where most of Toon Town's middle class citizens call home.
- Main article: Tenderloin
Close to the heart of Toon Town, Tenderloin is home of entertainment venues such as theaters and restaurants. The district is shaped uncannily like a steak, with the "eye" of it being Bologna Park.
- Main article: Urban Jungle
An island in the middle of the Mudson River, the Urban Jungle is a mix of towering skyscrapers and treetop canopy. With vine-swinging as common a method of transport as a taxi cab, it is an unusual district by any standards other than Toon Town's.
- Main article: Wrongside
Found on the other side of the railway tracks, Wrongside is a den of nefarious activity and the criminal element.